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SELECT PUBLICATIONS (click on thumbnail to download PDF)

2016 banner

Journal of Immunology

Critical role of LTB4/BLT1 in IL-23 induced synovial inflammation and osteoclastogenesis via NF-κB. Bouchareychas L, Grössinger EM, Kang M, Qiu H, and Adamopoulos IE. J Immunol. 2016 (in press).

Journal of Immunology

T Cell-Independent Mechanisms Associated with Neutrophil Extracellular Trap Formation and Selective Autophagy in IL-17A-Mediated Epidermal Hyperplasia. Suzuki E, Maverakis E, Sarin R, Bouchareychas L, Kuchroo VK, Nestle FO, Adamopoulos IE. J Immunol. 2016 Oct 24. pii: 1600383. [Epub ahead of print]

Arthritis Research and Therapy thumb

CD4+ Virtual Memory: Antigen-inexperienced T cells reside in the naive, regulatory, and memory T cell compartments at similar frequencies, implications for autoimmunity. Marusina AI, Ono Y, Merleev AA, Shimoda M, Ogawa H, Wang EA, Kondo K, Olney L, Luxardi G, Miyamura Y, Yilma TD, Bustos-Villalobos I, Bergstrom JW, Kronenberg DG, Soulika AM, Adamopoulos IE and Maverakis E. J Autoimmun 2016 Oct (in press).

Arthritis Research and Therapy thumb

Autophagy-linked FYVE containing protein WDFY3 interacts with TRAF6 and modulates RANKL-induced osteoclastogenesis. Wu DJ, Gu R, Sarin R, Zavodovskaya R, Chen CP, Christiansen BA, Adamopoulos IE. J Autoimmun. 2016 Sep;73:73-84. doi: 10.1016/j.jaut.2016.06.004.

Journal of Immunology

Interactions of the Immune System with Skin and Bone Tissue in Psoriatic Arthritis: A Comprehensive Review. Sukhov A, Adamopoulos IE, Maverakis E. Clin Rev Allergy Immunol. 2016 Aug;51(1):87-99. doi: 10.1007/s12016-016-8529-8. Review.

Arthritis Research and Therapy thumb

The critical role of toll-like receptors--From microbial recognition to autoimmunity: A comprehensive review. Jiménez-Dalmaroni MJ, Gerswhin ME, Adamopoulos IE. Autoimmun Rev. 2016 Jan;15(1):1-8. doi: 10.1016/j.autrev.2015.08.009. Review.

2015 banner

Arthritis Research and Therapy thumb

Autoimmune or Autoiflammatory? Bad to the Bone. Adamopoulos IE. Int J Clin Rheumtol. 2015;10(1):5-7

IL-17A gene transfer induces bone loss and epidermal hyperplasia associated with psoriatic arthritis IL-17A gene transfer induces bone loss and epidermal hyperplasia associated with psoriatic arthritis. Adamopoulos IE, Suzuki E, Chao CC, Gorman D, Adda S, Maverakis E, Zarbalis K, Geissler R, Asio A, Blumenschein WM, McClanahan T, De Waal Malefyt R, Gershwin ME, Bowman EP. Ann Rheum Dis. 2015 Jun;74(6):1284-92. doi: 10.1136/annrheumdis-2013-204782

Journal of Immunology Crosstalk among IL-23 and DNAX Activating Protein of 12 kDa-Dependent Pathways Promotes Osteoclastogenesis. Shin HS, Sarin R, Dixit N, Wu J, Gershwin E, Bowman EP, Adamopoulos IE.
J Immunol. 2015 Jan 1;194(1):316-24. doi: 10.4049/jimmunol.1401013

Nature Reviews Rheum Alternative pathways of osteoclastogenesis in inflammatory arthritis.
Adamopoulos IE and Mellins ED. Nat Rev Rheumatol. 2015 Mar;11(3):189-94. doi: 10.1038/nrrheum.2014.198. Review.

Liver thumb Anti-Kelch-like 12 and Anti-Hexokinase 1: Novel Autoantibodies in Primary Biliary Cirrhosis. Norman GL, Yang CY, Ostendorff HP, Shums Z, Lim MJ, Wang J, Awad A, Hirschfield GM, Milkiewicz P, Bloch DB, Rothschild KJ, Bowlus CL, Adamopoulos IE, Leung PS, Janssen HJ, Cheung AC, Coltescu C, Gershwin ME. Liver Int. 2015 Feb;35(2):642-51. doi: 10.1111/liv.12690

2014 banner

Arthritis Research and Therapy thumb Leukotriene B4 activates intracellular calcium and augments human osteoclastogenesis.
Dixit N, Wu DJ, Belgacem YH, Borodinsky LN, Gershwin M, Adamopoulos IE. Arthritis Res Ther. 2014 Dec 2;16(6):496. doi: 10.1186/s13075-014-0496-y

Nature and Communications thumb Loss of Wdfy3 in mice alters cerebral cortical neurogenesis reflecting aspects of the autism pathology. Orosco LA, Ross AP, Cates SL, Scott SE, Wu D, Sohn J, Pleasure D, Pleasure SJ, Adamopoulos IE, Zarbalis KS. Nat Commun. 2014 Sep 8;5:4692. doi: 10.1038/ncomms5692
Autoimmunity Reviews

The IL-23/IL-17 axis in psoriatic arthritis
Suzuki E, Mellins ED, Gershwin ME, Nestle FO, Adamopoulos IE. Autoimmun Rev. 2014 Apr-May;13(4-5):496-502. doi: 10.1016/j.autrev.2014.01.050. Review.

Jove thumbnail

A Novel In Vivo Gene Transfer Technique and In Vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders. Dennis J Wu, Neha Dixit, Thanh Nguyen, Erika Suzuki, Hyun Seock Shin, Jack Davis, Emanual Maverakis, Iannis E Adamopoulos. Journal or Visualized Experiments 2014 e51810, doi:10.3791/51810

2013 banner

Experimental Derm

NKG2C, HLA-E and their association with psoriasis
Patel F, Marusina AI, Duong C, Adamopoulos IE, Maverakis E. Exp Dermatol. 2013 Dec;22(12):797-9. doi: 10.1111/exd.12280

A mutation in mouse Pak1ip1 causes orofacial clefting while human PAK1IP1 maps to 6p24 translocation breaking points associated with orofacial clefting A mutation in mouse Pak1ip1 causes orofacial clefting while human PAK1IP1 maps to 6p24 translocation breaking points associated with orofacial clefting.  AP Ross, MA Mansilla, Y Choe, S Helminski, R Sturm, RL Maute, SR May, KK Hozyasz, P Wójcicki, A Mostowska, B Davidson, IE Adamopoulos, SJ Pleasure, JC Murray, KS Zarbalis. Plos One. 2013 Jul 25;8(7):e69333

The Implication of Vitamin D and Autoimmunity: a Comprehensive Review The Implication of Vitamin D and Autoimmunity: a Comprehensive Review
CY Yang, PS Leung, IE Adamopoulos, ME Gershwin. Clinical Reviews in Allergy & Immunology. 2013 Jan 29

The emerging role of Interleukin 27 in inflammatory arthritis The emerging role of Interleukin 27 in inflammatory arthritis
IE Adamopoulos, S Pflanz. and bone destruction. Cytokine Growth Factor Rev. 2013 Apr;24(2):115-21



Rheumatoid and pyrophosphate arthritis synovial fibroblasts induce osteoclastogenesis independently of RANKL, TNF and IL-6 signaling pathways Rheumatoid and pyrophosphate arthritis synovial fibroblasts induce osteoclastogenesis independently of RANKL, TNF and IL-6 signaling pathways. TJ Dickerson, E Suzuki, C Stanecki, HS Shin, H Qiu, IE Adamopoulos. Journal of Autoimmunity. 2012 Dec;39(4):369-76
IL-23 is critical for the induction of arthritis, osteoclast formation and maintenance of bone mass IL-23 is critical for the induction of arthritis, osteoclast formation and maintenance of bone mass. IE Adamopoulos, M Tessmer, CC Chao, S Adda, D Gorman, M Petro, CC Chu, RH Pierce, W Yao, NE Lane, D Laface, *EP Bowman. Journal of Immunology. 2011 Jul 15;187(2):951-9
Anti-IL-17A therapy protects against bone erosion in experimental models of rheumatoid arthritis Anti-IL-17A therapy protects against bone erosion in experimental models of rheumatoid arthritis. CC Chao, SJ Chen, IE Adamopoulos, N Davis, K Hong, A Vu, S Kwan, L Fayadat-Dilman, A Asio, EP Bowman. Autoimmunity. 2011 May;44(3):243-52
Myeloid DAP12- associating lectin (MDL)-1 receptor regulates synovial inflammation and bone erosion associated with autoimmune arthritis Myeloid DAP12-associating lectin (MDL)-1 receptor regulates synovial inflammation and bone erosion associated with autoimmune arthritis. B Joyce-Shaikh, M Bigler, CC Chao, E Murphy, IE Adamopoulos, P Heyworth, E Bowman, T McClanahan, J Phillips and DJ Cua*. Journal of Experimental Medicine. 2010 Mar 15;207(3):579-89
Structural, cellular, and molecular evaluation of bone erosion in experimental arthritis models: assessment by μCT, histology, and serum biomarkers Structural, cellular, and molecular evaluation of bone erosion in experimental arthritis models: assessment by μCT, histology, and serum biomarkers
CC Chao, SJ Chen, IE Adamopoulos, EP Bowman. Autoimmunity. 2010 Dec;43(8):642-53
IL-17A upregulates RANK on osteoclast precursors Interleukin-17A upregulates receptor activator of NF-kappaB on osteoclast precursors
IE Adamopoulos, CC Chao, R Geissler, DM Laface, W Blumenschein, T McClanahan and EP Bowman. Arthritis Research and Therapy. 2010 Feb 18;12(1):R29
A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis. Muchamuel T, Basler M, Aujay M, Suzuki E, Kalim K, Laurer C, Sylvain C, Ring E, Shields J, Jiang J, Shwonek P, Parlati F, Demo S.D, Bennett M.K, Kirk C.J and Groettrup M. Nature Medicine. 2009 Jul;15(7):781-7
Immune regulation of bone loss by Th17 cells Immune regulation of bone loss by Th17 cells
IE Adamopoulos and EP Bowman. Arthritis Research and Therapy. 2008;10(5):225
Fine mapping of the MHC Class III region demonstrates association of AIF1 and rheumatoid arthritis Fine mapping of the MHC Class III region demonstrates association of AIF1 and rheumatoid arthritis. SJ Harney, C Vilariño-Güell, IE Adamopoulos, AM Sims, RW Lawrence, LR Cardon, JL Newton, C Meisel, JJ Pointon, C Darke, NA Athanasou, BP Wordsworth, MA Brown. Rheumatology (Oxford). 2008 Dec;47(12):1761-7
Cellular and humoral mechanisms of osteoclast formation in Ewing’s Sarcoma Cellular and humoral mechanisms of osteoclast formation in Ewing’s Sarcoma
YS Lau, IE Adamopoulos, H Giele, CLMH Gibbons, NA Athanasou. British Journal of Cancer. 2007 Jun 4;96(11):1716-22
A novel computational method to quantify and analyse osteoclastic bone resorption A novel computational method to quantify and analyse osteoclastic bone resorption
IE Adamopoulos and K Pataridis. Journal of Computational Methods in Science and Engineering. 2007 Apr;7(2):87-91
Hepatocyte growth factor can substitute for M-CSF to support osteoclastogenesis Hepatocyte growth factor can substitute for M-CSF to support osteoclastogenesis
IE Adamopoulos, Z Xia, YS Lau, NA Athanasou. Biochemical and Biophysical Research Communications. 2006 Nov 17;350(2):478-83
Macrophage-mediated biodegradation of Poly (DL-lactide-co-glycolide) in vitro Macrophage-mediated biodegradation of Poly (DL-lactide-co-glycolide) in vitro
Z Xia, Y Huang, A Walpole, IE Adamopoulos, J Triffitt, Z Cui. Journal of Biomedical Materials Part A. 2006 Dec 1;79(3):582-90
Osteoclast differentiation and bone resorption in multicentric reticulohistiocytosis Osteoclast differentiation and bone resorption in multicentric reticulohistiocytosis
IE Adamopoulos, BP Wordsworth, JR Edwards, DJ Ferguson, NA Athanasou. Human Pathology. 2006 Sep;37(9):1176-85
Stimulation of osteoclast formation and resorption by inflammatory arthritis synovial fluid Stimulation of osteoclast formation and resorption by inflammatory arthritis synovial fluid
IE Adamopoulos, L Danks, I Itonaga, R Locklin, A Sabokbar, DJ Ferguson, NA Athanasou. Virchows Archives. 2006 Jul;449(1):69-77
In vitro biodegradation of three brushite calcium phosphate cements by a macrophage cell-line In vitro biodegradation of three brushite calcium phosphate cements by a macrophage cell-line
Z Xia, LM Grover, Y Huang, IE Adamopoulos, U Gbureck, JT Triffitt, RM Shelton, JE Barralet. Biomaterials. 2006 Sep;27(26):4557-65
LIGHT (TNFSF14), a novel mediator of bone resorption, is elevated in rheumatoid arthritis LIGHT (TNFSF14), a novel mediator of bone resorption, is elevated in rheumatoid arthritis
JR Edwards, S Sun, R Locklin, C Shipman, IE Adamopoulos, NA Athanasou, A Sabokbar. Arthritis and Rheumatism. 2006 May;54(5):1451-62
Hepatocyte growth factor in normal and diseased bone and joint tissues Hepatocyte growth factor in normal and diseased bone and joint tissues
IE Adamopoulos and NA Athanasou. Current Rheumatology Reviews. 2006;2(1):1-7
Synovial fluid macrophages are capable of osteoclast Synovial fluid macrophages are capable of osteoclast formation and resorption
IE Adamopoulos, A Sabokbar, BP Wordsworth, A Carr, DJ Ferguson, NA Athanasou. Journal of Pathology. 2006 Jan;208(1):35-43